The challenges of heat sterilization of peritoneal dialysis solutions: is there an alternative?

Peritoneal dialysis (PD) solutions are currently sterilized in an autoclave using high-temperature saturated steam. Although thermal methods are an effective means of sterilization, the heating of PD solutions results in the formation of toxic glucose degradation products (GDPs). Here, we review basic concepts in the sterilization of PD solutions and discuss possible alternatives to steam sterilization, including filtration, ohmic heat, ionizing radiation, and pulsed ultraviolet light. Although the latter methods have several advantages, many also have prohibitive limitations or have not been adequately studied for use on PD solutions. Thus, in the absence of suitable alternatives, conventional heat sterilization, in combination with low-GDP manufacturing practices, remains the best option at the present time.

Citation

Conor T Hanrahan, Rainer Himmele, Jose A Diaz-Buxo. The challenges of heat sterilization of peritoneal dialysis solutions: is there an alternative? Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 2012;28:126-30

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PMID: 23311228

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