Highly efficient synthesis of 3a,6a-dihydrofuro[2,3-b]furans via a novel bicyclization.

Wen-Ming Shu, Yan Yang, Dong-Xue Zhang, Liu-Ming Wu, Yan-Ping Zhu, Guo-Dong Yin, An-Xin Wu

Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, PR China.

Organic letters 2013 Feb 1

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A highly efficient method for the construction of 3a,6a-dihydrofuro[2,3-b]furan derivatives has been developed via a novel bicyclization, which is very valuable for the synthesis of fused furofuran compounds since it is time-saving and catalyst-free. Based on the bicyclization, a coupled domino strategy has been developed to directly construct 3a,6a-dihydrofuro[2,3-b]furan derivatives from methyl ketones.

Citation

Wen-Ming Shu, Yan Yang, Dong-Xue Zhang, Liu-Ming Wu, Yan-Ping Zhu, Guo-Dong Yin, An-Xin Wu. Highly efficient synthesis of 3a,6a-dihydrofuro[2,3-b]furans via a novel bicyclization. Organic letters. 2013 Feb 1;15(3):456-9