Ken Shinmura is at the Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. shimmura@z5.keio.jp
Trends in cardiovascular medicine 2013 JanIncreasing evidence demonstrates that members of the sirtuin family, most of which work as NAD(+)-dependent protein deacetylases, mediate the preferable effects of caloric restriction. Since mitochondria play a central role in cardiac reactive oxygen species production, targeted modification of mitochondrial proteins and subsequent improvement in mitochondrial function have the potential for controlling cardiovascular senescence and managing cardiovascular diseases such as ischemia/reperfusion. We showed that caloric restriction primes cardiac mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. We speculate that deacetylation of specific mitochondrial proteins by sirtuin preserves mitochondrial function and attenuates myocardial oxidative damage during ischemia/reperfusion. Copyright © 2013 Elsevier Inc. All rights reserved.
Ken Shinmura. Post-translational modification of mitochondrial proteins by caloric restriction: possible involvement in caloric restriction-induced cardioprotection. Trends in cardiovascular medicine. 2013 Jan;23(1):18-25
PMID: 23312135
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