Mechanisms of epoxyeicosatrienoic acids to improve cardiac remodeling in chronic renal failure disease.

Kun Zhang, Ju Wang, Huanji Zhang, Jie Chen, Zhiyi Zuo, Jingfeng Wang, Hui Huang

Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

European journal of pharmacology 2013 Feb 15

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Both clinical and basic science studies have demonstrated that cardiac remodeling in patients with chronic renal failure (CRF) is very common. It is a key feature during the course of heart failure and an important risk factor for subsequent cardiac mortality. Traditional drugs or therapies rarely have effects on cardiac regression of CRF and cardiovascular events are still the first cause of death. Epoxyeicosatrienoic acids (EETs) are the products of arachidonic acids metabolized by cytochrome P450 epoxygenases. It has been found that EETs have important biological effects including anti-hypertension and anti-inflammation. Recent data suggest that EETs are involved in regulating cardiomyocyte injury, renal dysfunction, chronic kidney disease (CKD)-related risk factors and signaling pathways, all of which play key roles in cardiac remodeling induced by CRF. This review analyzes the literature to identify the possible mechanisms for EETs to improve cardiac remodeling induced by CRF and indicates the therapeutic potential of EETs in it. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Kun Zhang, Ju Wang, Huanji Zhang, Jie Chen, Zhiyi Zuo, Jingfeng Wang, Hui Huang. Mechanisms of epoxyeicosatrienoic acids to improve cardiac remodeling in chronic renal failure disease. European journal of pharmacology. 2013 Feb 15;701(1-3):33-9