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Boger et al. synthesized a series of C20' urea derivatives of vinblastine that matched or exceeded the potency of vinblastine in cell growth inhibition assays. The studies demonstrated the importance of the H-bond donor on the C20' position and revealed the presence of a space surrounding the C20' substituent that tolerates a wide variety of substituents, remarkably enhancing potency of vinblastine analogues.

Citation

Romano Silvestri. New prospects for vinblastine analogues as anticancer agents. Journal of medicinal chemistry. 2013 Feb 14;56(3):625-7

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PMID: 23316748

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