Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase.

Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang, Xiangshi Tan

Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.

Chemical communications (Cambridge, England) 2013 Feb 18

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Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O(2)(˙-) disproportionation, and exhibit impressive Ni-SOD activity.

Citation

Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang, Xiangshi Tan. Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase. Chemical communications (Cambridge, England). 2013 Feb 18;49(14):1452-4