Fatal poisoning by isoniazid and rifampicin.

Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convulsions. Sometimes, it may produce red man syndrome. We report a case of fatal poisoning with isoniazid and rifampicin. The case was characterized by late presentation, lactic acidosis, and renal failure.

Citation

A Sridhar, Y Sandeep, C Krishnakishore, P Sriramnaveen, Y Manjusha, V Sivakumar. Fatal poisoning by isoniazid and rifampicin. Indian journal of nephrology. 2012 Sep;22(5):385-7

PMID: 23326053

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