Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy.

Josef Ben-Ari, Meidad Greenberg, Dan Nemet, Evgeny Edelstein, Alon Eliakim

Department of Pediatric, Tel-Aviv University, Israel.

Journal of pediatric endocrinology & metabolism : JPEM 2013

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Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the most common cause of persistent hypoglycemia in the neonatal period and infancy, is a genetic disorder characterized by abnormal regulation of insulin secretion. Octreotide, a somatostatin analog, is often used as a second-line treatment when diazoxide therapy fails to control hypoglycemia. We report herein a rare development of octreotide-induced hepatitis following prolonged treatment for PHHI in an infant. Octreotide-induced hepatitis may occur mostly when high doses are given, or when dosing is increased. This warrants routine examination of liver function. When hepatitis develops, prompt cessation of octreotide therapy will probably result in subsequent resolution.

Citation

Josef Ben-Ari, Meidad Greenberg, Dan Nemet, Evgeny Edelstein, Alon Eliakim. Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy. Journal of pediatric endocrinology & metabolism : JPEM. 2013;26(1-2):179-82