Labdane-type diterpenoids from the fruits of Vitex trifolia.

Cheng-Jian Zheng, Jian-Yong Zhu, Wu Yu, Xue-Qin Ma, Khalid Rahman, Lu-Ping Qin

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.

Journal of natural products 2013 Feb 22

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Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg/mL).

Citation

Cheng-Jian Zheng, Jian-Yong Zhu, Wu Yu, Xue-Qin Ma, Khalid Rahman, Lu-Ping Qin. Labdane-type diterpenoids from the fruits of Vitex trifolia. Journal of natural products. 2013 Feb 22;76(2):287-91