Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age.

Mental Health Research Institute, Siberian division of Russian Academy of Medical Sciences, Tomsk, Russia. f_o_y@mail.ru

Bulletin of experimental biology and medicine 2012 Nov

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Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.

Citation

O Yu Fedorenko, N A Bokhan, S A Ivanova. Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age. Bulletin of experimental biology and medicine. 2012 Nov;154(1):44-6