Blockade of different subtypes of α(1)-adrenoceptors produces opposite effect on heart chronotropy in newborn rats.

N I Ziyatdinova, R E Dementieva, L I Fashutdinov, T L Zefirov

Department of Anatomy, Physiology, and Human Health Protection, Kazan (Privolzhskii) Federal University, Russia.

Bulletin of experimental biology and medicine 2012 Dec

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We compared the effects of blockade of α(1A)-, α(1B)-, and α(1D)-subtypes of α(1)-adrenoceptors on the cardiac rhythm in newborn rats. Different responses of the heart were observed after blockade of several subtypes of α(1)-adrenoceptors. Administration of WB 4101, a selective blocker of α(1A)-adrenoceptors, increased heart rate, while blockade of α(1AD)-adrenoceptors with BMY 7378 decelerated of heart rhythm. Blockade of α(1B)-adrenoceptors with chloroethylclonidine produced no significant effects on heart chronotropy.

Citation

N I Ziyatdinova, R E Dementieva, L I Fashutdinov, T L Zefirov. Blockade of different subtypes of α(1)-adrenoceptors produces opposite effect on heart chronotropy in newborn rats. Bulletin of experimental biology and medicine. 2012 Dec;154(2):184-5