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Widespread usage of herbs as supplements or medicines raises the potential of herb-drug interactions (HDIs). Basically, HDIs occur by pharmacokinetic and/or pharmacodynamic pathways. Nuclear receptors (NRs) are a class of transcription factors whose role in drug interactions has been defined. A large number of herbs activate NRs, resulting in HDIs. NR-mediated HDIs are similar to drug-drug interactions, but are more complicated because of the presence of multiple compounds in herbs. Dosage and therapeutic sequence as well as various other factors, including the patient's gender, age, and genetic makeup, may affect outcomes of NR-mediated HDIs.

Citation

Madhav Sachar, Xiaochao Ma. Nuclear receptors in herb-drug interactions. Drug metabolism reviews. 2013 Feb;45(1):73-8

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PMID: 23330543

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