School of Chemistry, Trinity College Dublin, Trinity Biomedical Sciences Insitute, 152-160 Pearse Street, Dublin 2, Ireland.
Organic letters 2013 Feb 1The use of intramolecular thiyl radical cyclizations for the synthesis of thiosugars has been investigated, and a new free-radical-based methodology for the synthesis of biologically important thiosugars has been developed. The methodology is mild and proceeds via either 6-endo or 5-exo cyclization to furnish the thiosugar ring. This represents the first examples of thiyl radical cyclization being applied to the synthesis of thiosugars.
Aoife Malone, Eoin M Scanlan. Applications of thiyl radical cyclizations for the synthesis of thiosugars. Organic letters. 2013 Feb 1;15(3):504-7
PMID: 23330717
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