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The aim of this study was to evaluate the biocompatibility of mineral trioxide aggregate (MTA) Bio and Portland cement (PC) and compare with those of ProRoot MTA. Polyethylene tubes were filled with materials and placed into dorsal subcutaneous connective tissue of Wistar albino rats. After 7, 30, and 60 days after the surgical procedure, the implants with the surrounding tissue were removed. Tissue samples were subjected to histological processing, and sections were stained with hematoxylin and eosin. Sections were evaluated for the intensity of inflammation, predominant cell type, presence of fibrous capsule and granulation tissue. Data were submitted to Kruskal-Wallis test at a significant level of P ≤ 0.05. No statistical differences were observed at any evaluated condition among tested materials (P > 0.05). Statistically significant differences were observed between mean inflammatory scores, cell types and granulation tissue of the same material in different experimental periods (P < 0.05). Can be concluded that biocompatibility of MTA bio and PC were comparable with that of ProRoot MTA. Copyright © 2013 Wiley Periodicals, Inc.


Lucio Mitsuo Kurita, Roberta Barroso Cavalcante, Eduardo Diogo Gurgel-Filho, Gustavo André De-Deus, Ana Beatriz Ximenes, Emmanuel João Nogueira Leal Da Silva. Response of mice connective tissue to three different endodontic materials. Microscopy research and technique. 2013 Mar;76(3):311-5

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PMID: 23335503

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