Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China].

To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES) -403G/A, -28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection, among people with Dong and Han ethnicities, in Guizhou. A total of 229 individuals with HBV persistence infection, 161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities. Allelic frequencies of both RANTES-403G/A and -28C/G were identified by TaqMan-MGB probe. Both RANTES-403G/A and -28C/G polymorphism in the HBV-persistent group, when compared to the HBV-clearances group, no significant difference was found (P > 0.05). from the univariate analysis showed that subjects carrying -403AG and -28GG genotype had higher risk on the susceptibility to HBV persistence infection. The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P < 0.05). There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities. Patients that carrying both RANTES-403AG and -28GG genotype had higher risk on the persistence to HBV, while RANTES-403A had contributed to the clearance of HBV infection.

Citation

Chan Zhang, Ke-ren Shan, Yan He, Chan-juan Wang, Ting Zhang, Yi Li, Jie Deng, Lin-jie Li, Kai Ouyang, Zhi-zhong Guan. Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2012 Dec;33(12):1279-82

PMID: 23336202

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