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The main indication of prophylactic mastectomy pertains to BRCA1 or BRCA2 mutation carriers. Prophylactic mastectomy includes the simple method and the subcutaneous method. Both methods can be followed by breast plastic reconstruction either at the same time or later. This review examines key issues regarding prophylactic mastectomy: the selection of patients, its effectiveness, its limitations, convergence/divergence in existing guidelines, and future perspectives.


Flora Zagouri, Dimosthenis T Chrysikos, Theodoros N Sergentanis, Georgia Giannakopoulou, Constantine G Zografos, Christos A Papadimitriou, George C Zografos. Prophylactic mastectomy: an appraisal. The American surgeon. 2013 Feb;79(2):205-12

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PMID: 23336662

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