Control of disease activity and tumor size after introduction of pegvisomant in a lanreotide-resistant acromegalic patient.

Salha Fendri, Pelin Karaca, Evelyne Tiev, Michael Buchfelder, Jean-Daniel Lalau

Service d'endocrinologie-nutrition, hôpital Sud, université Picardie-Jules-Verne, centre hospitalier universitaire, 80054 Amiens, France.

Annales d'endocrinologie 2013 Feb

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We report on a 30-year-old female acromegalic patient treated with the growth hormone (GH) receptor antagonist pegvisomant at a low dose after the failure of long-acting lanreotide, neurosurgery and radiotherapy treatment to restore IGF-1 levels. The combination treatment was well tolerated and produced a dramatic improvement in the patient's condition (reduction in visual field defects, relief of headache and excessive perspiration), normalization of IGF-I levels and a considerable decrease in tumor size, enabling a dramatic decrease in lanreotide dosage and, ultimately, its withdrawal. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Citation

Salha Fendri, Pelin Karaca, Evelyne Tiev, Michael Buchfelder, Jean-Daniel Lalau. Control of disease activity and tumor size after introduction of pegvisomant in a lanreotide-resistant acromegalic patient. Annales d'endocrinologie. 2013 Feb;74(1):49-52