Electric-field induced mutation of DNA: a theoretical investigation of the GC base pair.

CEISAM, UMR CNRS 6230, Université de Nantes, 2, Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France. jose.ceron@univ-nantes.fr

Physical chemistry chemical physics : PCCP 2013 Apr 7

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It is known that intense external electric fields affect the proton transfer (PT) reactions in simple chemical systems, such as hydrated chlorhydric acid or formic acid dimer. Accordingly, electric fields might be used to modulate the PT reactions responsible for the spontaneous mutation mechanism in DNA. In this contribution, we investigate the effect of these fields on the tautomeric equilibria of the guanine-cytosine (GC) base pair in order to gain further insight into this hypothesis. This task is performed with both density functional theory (DFT) and second-order Møller-Plesset (MP2) approaches. Our results demonstrate that electric fields not only drastically alter the rate constants of PT but also tune the mechanism of the PT reactions in the GC base pair.

Citation

José P Cerón-Carrasco, Denis Jacquemin. Electric-field induced mutation of DNA: a theoretical investigation of the GC base pair. Physical chemistry chemical physics : PCCP. 2013 Apr 7;15(13):4548-53