Caffeine consumption and risk of dyskinesia in CALM-PD.

Movement disorders : official journal of the Movement Disorder Society 2013 Mar

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Adenosine A2A receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia. We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa. For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05). These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia. Copyright © 2013 Movement Disorder Society.

Citation

Anne-Marie A Wills, Shirley Eberly, Marsha Tennis, Anthony E Lang, Susan Messing, Daniel Togasaki, Caroline M Tanner, Cornelia Kamp, Jiang-Fan Chen, David Oakes, Michael P McDermott, Michael A Schwarzschild, Parkinson Study Group. Caffeine consumption and risk of dyskinesia in CALM-PD. Movement disorders : official journal of the Movement Disorder Society. 2013 Mar;28(3):380-3