Single-molecule DNA detection using a novel SP1 protein nanopore.

Hai-Yan Wang, Yang Li, Li-Xia Qin, Arnon Heyman, Oded Shoseyov, Itamar Willner, Yi-Tao Long, He Tian

Key Laboratory for Advanced Materials and Institute of Fine Chemicals & Department of Chemistry, East China University of Science and Technology Shanghai, PR China.

Chemical communications (Cambridge, England) 2013 Feb 28

filter terms:

SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.

Citation

Hai-Yan Wang, Yang Li, Li-Xia Qin, Arnon Heyman, Oded Shoseyov, Itamar Willner, Yi-Tao Long, He Tian. Single-molecule DNA detection using a novel SP1 protein nanopore. Chemical communications (Cambridge, England). 2013 Feb 28;49(17):1741-3