Chromatin dynamics at the replication fork: there's more to life than histones.

Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins--including histones--must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance. Published by Elsevier Ltd.

Citation

Iestyn Whitehouse, Duncan J Smith. Chromatin dynamics at the replication fork: there's more to life than histones. Current opinion in genetics & development. 2013 Apr;23(2):140-6

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PMID: 23347596

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