ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.

Marshall S Horwitz, Seth J Corey, H Leighton Grimes, Timothy Tidwell

Hematology/oncology clinics of North America 2013 Feb

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The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant disorder in which neutrophil counts fluctuate with 21-day periodicity. SCN consists of static neutropenia, with promyelocytic maturation arrest in the bone marrow. Unlike CN, SCN displays frequent acquisition of somatic mutations in the gene CSF3R. CN is caused by heterozygous mutations in the gene ELANE, encoding neutrophil elastase. SCN is genetically heterogeneous but is most frequently associated with ELANE mutations. We discuss how the mutations provide clues into the pathogenesis of neutropenia and describe current hypotheses for its molecular mechanisms. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Marshall S Horwitz, Seth J Corey, H Leighton Grimes, Timothy Tidwell. ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology. Hematology/oncology clinics of North America. 2013 Feb;27(1):19-41, vii