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Original TDAE strategy using propargylic chloride: rapid access to 1,4-diarylbut-3-ynol derivatives.
Molecules (Basel, Switzerland) 2013 Jan 25Sizes of these terms reflect their relevance to your search.
We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino)ethylene (TDAE) as reductant.
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Manon Roche, Thierry Terme, Patrice Vanelle. Original TDAE strategy using propargylic chloride: rapid access to 1,4-diarylbut-3-ynol derivatives. Molecules (Basel, Switzerland). 2013 Jan 25;18(2):1540-8
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PMID: 23353124
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