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S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal that this modification plays a critical role for pathogens of all kinds and at multiple steps of their life cycle. The present review examines the involvement of S-palmitoylation in infection by viruses, bacteria and parasites and illustrates how pathogens have evolved to manipulate the host palmitoylation machinery.

Citation

Mathieu Blanc, Sanja Blaskovic, F Gisou van der Goot. Palmitoylation, pathogens and their host. Biochemical Society transactions. 2013 Feb 1;41(1):84-8

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PMID: 23356263

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