C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome.

The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and tRNA in Nanoarchaeum equitans. The minimal and fragmented genome of this tiny archaeon permits a sequencing depth that enables the identification of processing intermediates in the study of RNA processing pathways. These intermediates include circular C/D box sRNA molecules and tRNA half precursors.

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Hagen Richter, Sabine Mohr, Lennart Randau. C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome. Biochemical Society transactions. 2013 Feb 1;41(1):411-5

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PMID: 23356320

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