Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect.

Eugen J Verspohl, Hajime Fujii, Kohei Homma, Sybille Buchwald-Werner

Department of Pharmacology, Institute of Medicinal Chemistry, University of Münster, Münster, Germany. verspoh@uni-muenster.de

Phytomedicine : international journal of phytotherapy and phytopharmacology 2013 Mar 15

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Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health. Copyright © 2012 Elsevier GmbH. All rights reserved.

Citation

Eugen J Verspohl, Hajime Fujii, Kohei Homma, Sybille Buchwald-Werner. Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Mar 15;20(5):427-31