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Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.


Shigeo Masuda, Mo Li, Juan Carlos Izpisua Belmonte. Niche-less maintenance of HSCs by 2i. Cell research. 2013 Apr;23(4):458-9

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PMID: 23357848

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