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New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wei Zhang, Jeffrey L Fortman, Jacob C Carlson, Jinyong Yan, Yi Liu, Fali Bai, Wenna Guan, Junyong Jia, Teatulohi Matainaho, David H Sherman, Shengying Li. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. Chembiochem : a European journal of chemical biology. 2013 Feb 11;14(3):301-6

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PMID: 23362147

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