Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up.

Eva Tufvesson, Olle Melander, Lennart Minthon, Margaretha Persson, Peter M Nilsson, Joachim Struck, Katarina Nägga

Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. eva.tufvesson@gmail.com

Dementia and geriatric cognitive disorders 2013

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We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT). Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance. Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up. Copyright © 2013 S. Karger AG, Basel.

Citation

Eva Tufvesson, Olle Melander, Lennart Minthon, Margaretha Persson, Peter M Nilsson, Joachim Struck, Katarina Nägga. Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up. Dementia and geriatric cognitive disorders. 2013;35(1-2):67-76