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A 31-year-old woman contracted acute varicella at 13 weeks of gestation. Severe hydrops fetalis, hepatomegaly, and intrauterine fetal death were detected at 16 weeks of gestation by ultrasound examinations. An examination at autopsy, histopathology, and polymerase chain reaction (PCR) provided evidence of varicella-zoster virus (VZV) infection of the fetus. Second trimester intrauterine fetal death caused by mother to fetus infection of VZV is extremely rare. Copyright © 2013 Wiley Periodicals, Inc.

Citation

Kenji Tanimura, Nobue Kojima, Takashi Yamazaki, Shuho Semba, Hiroshi Yokozaki, Hideto Yamada. Second trimester fetal death caused by varicella-zoster virus infection. Journal of medical virology. 2013 May;85(5):935-8

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PMID: 23364880

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