Diffusion coefficients of phenylbutazone in supercritical CO2 and in ethanol.

Chang Yi Kong, Kou Watanabe, Toshitaka Funazukuri

Department of Applied Chemistry and Biochemical Engineering, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku Naka-ku, Hamamatsu 432-8561, Japan. tcykong@ipc.shizuoka.ac.jp

Journal of chromatography. A 2013 Mar 1

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The diffusion coefficients D(12) of phenylbutazone at infinite dilution in supercritical CO(2) were measured by the chromatographic impulse response (CIR) method. The measurements were carried out over the temperature range from 308.2 to 343.2 K at pressures up to 40.0 MPa. In addition, the D(12) data of phenylbutazone at infinite dilution in ethanol were also measured by the Taylor dispersion method at 298.2-333.2K and at atmospheric pressure. The D(12) value of phenylbutazone increased from 4.45×10(-10) m(2) s(-1) at 298.2 K and 0.1 MPa in ethanol to about 1.43×10(-8) m(2) s(-1) at 343.2 K and 14.0 MPa in supercritical CO(2). It was found that all diffusion data of phenylbutazone measured in this study in supercritical CO(2) and in ethanol can be satisfactorily represented by the hydrodynamic equation over a wide range of fluid viscosity from supercritical state to liquid state with average absolute relative deviation of 5.4% for 112 data points. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Chang Yi Kong, Kou Watanabe, Toshitaka Funazukuri. Diffusion coefficients of phenylbutazone in supercritical CO2 and in ethanol. Journal of chromatography. A. 2013 Mar 1;1279:92-7