Direct ortho-arylation of ortho-substituted benzoic acids: overriding Pd-catalyzed protodecarboxylation.
Carlos Arroniz, Alan Ironmonger, Gerry Rassias, Igor Larrosa
Queen Mary University of London, School of Biological and Chemical Sciences, Joseph Priestley Building, Mile End Road, London E1 4NS, United Kingdom.
Organic letters 2013 Feb 15ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
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Carlos Arroniz, Alan Ironmonger, Gerry Rassias, Igor Larrosa. Direct ortho-arylation of ortho-substituted benzoic acids: overriding Pd-catalyzed protodecarboxylation. Organic letters. 2013 Feb 15;15(4):910-3
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PMID: 23373630
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