Catalytic hydrotrifluoromethylation of unactivated alkenes.

Satoshi Mizuta, Stefan Verhoog, Keary M Engle, Tanatorn Khotavivattana, Miriam O'Duill, Katherine Wheelhouse, Gerasimos Rassias, Maurice Médebielle, Véronique Gouverneur

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.

Journal of the American Chemical Society 2013 Feb 20

filter terms:

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF(3) source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)(3)Cl(2); the process is characterized by its operational simplicity and functional group tolerance.

Citation

Satoshi Mizuta, Stefan Verhoog, Keary M Engle, Tanatorn Khotavivattana, Miriam O'Duill, Katherine Wheelhouse, Gerasimos Rassias, Maurice Médebielle, Véronique Gouverneur. Catalytic hydrotrifluoromethylation of unactivated alkenes. Journal of the American Chemical Society. 2013 Feb 20;135(7):2505-8