Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction.

Mark D Tarn, Giancarlo Pascali, Francesco De Leonardis, Paul Watts, Piero A Salvadori, Nicole Pamme

Department of Chemistry, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.

Journal of chromatography. A 2013 Mar 8

filter terms:

Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [(18)F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [(18)F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Mark D Tarn, Giancarlo Pascali, Francesco De Leonardis, Paul Watts, Piero A Salvadori, Nicole Pamme. Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction. Journal of chromatography. A. 2013 Mar 8;1280:117-21