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This review is devoted to substantiation of new characteristics for classification of living organisms. The novel view of a role of flexible regions in protein functioning and evolution is suggested. It is based on the newly revealed correlation between the number of loops in elongation factors and the complexity of organisms. This correlation allowed us to formulate a hypothesis of evolution of this protein family. In addition, the study of the ribosomal protein S1 family made it possible to consider the number of structural domains as a reliable indicator of a microorganism's affiliation with a particular division and to judge about "direction" of their evolution. The findings allow us to consider the loops and repeats in these proteins as unique imprints of molecular evolution.


E I Deryusheva, O M Selivanova, I N Serdyuk. Loops and repeats in proteins as footprints of molecular evolution. Biochemistry. Biokhimii͡a. 2012 Dec;77(13):1487-99

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PMID: 23379524

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