Maternal seizure disorder and risk of adverse pregnancy outcomes.

Jessica A McPherson, Lorie M Harper, Anthony O Odibo, Kimberly A Roehl, Alison G Cahill

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. mcphersonj@wudosis.wustl.edu

American journal of obstetrics and gynecology 2013 May

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We sought to estimate the association between maternal seizure disorder and adverse pregnancy outcomes. We performed a retrospective cohort study of singleton, nonanomalous pregnancies. Women with self-reported seizure disorder were compared to women without medical problems. The primary outcome was intrauterine growth restriction (IUGR) <10th percentile. Secondary outcomes included IUGR <5th percentile, stillbirth, preeclampsia, and preterm delivery. A sensitivity analysis was performed using women who reported using antiepileptics to estimate the impact of disease severity on pregnancy outcomes. Of 47,118 women, 440 reported a seizure disorder. Women with seizure disorder were not at increased risk of IUGR <10th percentile (adjusted odds ratio, 1.11; 95% confidence interval, 0.82-1.50), IUGR <5th percentile, stillbirth, preeclampsia, or preterm delivery. The results were similar in the sensitivity analysis of women taking antiseizure medications. Our results suggest women with a seizure disorder are not at increased risk of IUGR, stillbirth, preeclampsia, or preterm delivery. Copyright © 2013 Mosby, Inc. All rights reserved.

Citation

Jessica A McPherson, Lorie M Harper, Anthony O Odibo, Kimberly A Roehl, Alison G Cahill. Maternal seizure disorder and risk of adverse pregnancy outcomes. American journal of obstetrics and gynecology. 2013 May;208(5):378.e1-5