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Globotriaosylceramide (Gb(3)) is a cell surface-expressed natural resistance factor for HIV infection, but, its expression in human T-cells remains unknown. Therefore, Gb(3) in resting or activated CD4(+) T-cells was assessed by flow cytometry and thin layer chromatography of cell extracts. We found the majority of CD4(+) T-cells, whether resting or activated, do not express Gb(3) at significant levels (<2% positive cells). Thus, HIV treatment or prevention strategies must focus on development of soluble Gb(3) analogues for inhibition of HIV infection.


Minji Kim, Beth Binnington, Darinka Sakac, Clifford A Lingwood, Donald R Branch. CD4(+) T-cells are unable to express the HIV natural resistance factor globotriosylceramide. AIDS (London, England). 2013 Mar 27;27(6):1029-32

PMID: 23380967

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