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Protonated adrenaline (PAd) can be oxidized to protonated adrenaline quinone (PAdquinone) through a one-step, two-electron redox reaction. The electron-transfer property of PAd and its supramolecular complex with glycine has been investigated by cyclic voltammetry (CV) experiment and theoretical calculations. From CV curves, the conditional formal redox potential E°' of PAd/PAdquinone couple at the pH value of 0.29 is determined to be 0.540 V. The calculated E°' using the G3MP2//B3LYP method and the B3LYP method with 6-31G(d,p), 6-31+G(d,p), 6-311G(d,p), and B3LYP/6-311+G(d,p) basis sets are in reasonable agreement with the experimental value. PAd can form supramolecular complex (PAd-Gly) with glycine (Gly) through hydrogen bond (H-bond), and the calculated E°' values of PAd-Gly/PAdquinone-Gly redox couple are larger than those of PAd/PAdquinone couple. The theoretical results are in good agreement with the experimental finding that the formation of H-bonds weaken the electron-donating ability of PAd.


Tao Liu, Chunmei Du, Zhangyu Yu, Lingli Han, Dongju Zhang. Prediction of redox potentials of adrenaline and its supramolecular complex with glycine: theoretical and experimental studies. The journal of physical chemistry. B. 2013 Feb 21;117(7):2081-7

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PMID: 23384015

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