Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.

Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators. © 2013 Blackwell Publishing Ltd.

Citation

Julie A Peterson, Janice G McFarland, Brian R Curtis, Richard H Aster. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. British journal of haematology. 2013 Apr;161(1):3-14

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PMID: 23384054

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