Emerging mechanisms of T-tubule remodelling in heart failure.

Ang Guo, Caimei Zhang, Sheng Wei, Biyi Chen, Long-Sheng Song

Cardiovascular research 2013 May 01

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Cardiac excitation-contraction coupling occurs primarily at the sites of transverse (T)-tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the instantaneous excitation and synchronous activation of nearly all Ca(2+) release sites throughout the large ventricular myocyte. Because of the critical roles played by T-tubules and the array of channels and transporters localized to the T-tubule membrane network, T-tubule architecture has recently become an area of considerable research interest in the cardiovascular field. This review will focus on the current knowledge regarding normal T-tubule structure and function in the heart, T-tubule remodelling in the transition from compensated hypertrophy to heart failure, and the impact of T-tubule remodelling on myocyte Ca(2+) handling function. In the last section, we discuss the molecular mechanisms underlying T-tubule remodelling in heart disease.

Citation

Ang Guo, Caimei Zhang, Sheng Wei, Biyi Chen, Long-Sheng Song. Emerging mechanisms of T-tubule remodelling in heart failure. Cardiovascular research. 2013 May 01;98(2):204-15