Biweekly Docetaxel and S-1 combination chemotherapy as first-line treatment for elderly patients with advanced gastric cancer.

Department of Surgery, Gastroenterological Center, Yokohama City University, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan. s0714@med.yokohama-cu.ac.jp

Anticancer research 2013 Feb

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This study assessed the toxicity and activity of biweekly docetaxel and S-1 combination therapy in elderly patients with advanced gastric cancer. One-hundred and thirteen patients were enrolled: 35 were 75 years old or more. The objective response rate, toxicity, progression-free survival (PFS), and overall survival (OS) were compared. Dose reduction was significantly frequent in the elderly group (24/35 versus 25/78, p<0.001). The overall response rate was 54.9%. Out of these, 18 (15.9%) underwent gastrectomy (13 R0 gastrectomy). The median OS was 17.3 months and the median PFS was 8.0 months. Neutropenia was the most frequently observed hematological toxicity at grade 3 and 4 (34.5%), followed by leukopenia (24.8%). Most non-hematological toxicities were of grade 1 or 2. There were no significant differences in overall response rate, median OS, median PFS, or toxicities between the two groups. This combination offers favourable survival benefits with controllable tolerance for therapy of AGC in the elderly.

Citation

Chikara Kunisaki, Masazumi Takahashi, Hidetaka A Ono, Shinichi Hasegawa, Kazuhito Tsuchida, Takashi Oshima, Mitsuyoshi Ota, Tadao Fukushima, Motohiko Tokuhisa, Yusuke Izumisawa, Ryo Takagawa, Jun Kimura, Takashi Kosaka, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo. Biweekly Docetaxel and S-1 combination chemotherapy as first-line treatment for elderly patients with advanced gastric cancer. Anticancer research. 2013 Feb;33(2):697-704