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Increased cobalt levels have been associated with neurological diseases (hand tremor, incoordination, cognitive decline, depression, vertigo, hearing loss and visual changes) in addition to "classic" and known cardiac diseases (arrhythmias and cardiomyopathies) and allergic or endocrine symptoms. Cobalt neurotoxicity is reported in isolated cases: old occupational or iatrogenic exposures and more recent releases of metallic ions by prosthesis. The studies of these cases have revealed a typical symptomatology of cobalt probably due to its ability to induce oxidative stress and mitochondrial alterations.


S Catalani, P Apostoli. Neurotoxic effects of cobalt: an open question]. Giornale italiano di medicina del lavoro ed ergonomia. 2011 Jul-Sep;33(3 Suppl):57-60

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PMID: 23393801

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