Understanding metabolic regulation and its influence on cell physiology.

Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased exponentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Christian M Metallo, Matthew G Vander Heiden. Understanding metabolic regulation and its influence on cell physiology. Molecular cell. 2013 Feb 07;49(3):388-98

Mesh Tags

PMID: 23395269

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