Interaction of insulin-like growth factor-binding protein 2 with α2-macroglobulin in the circulation.

Miloš Šunderić, Goran Miljuš, Olgica Nedić

The protein journal 2013 Feb

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Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with α2-macroglobulin (α2M), a protease inhibitor. Formation of IGFBP-2/α2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.

Citation

Miloš Šunderić, Goran Miljuš, Olgica Nedić. Interaction of insulin-like growth factor-binding protein 2 with α2-macroglobulin in the circulation. The protein journal. 2013 Feb;32(2):138-42