The inner blood-retinal barrier: molecular structure and transport biology.

Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan. hosoyak@pha.u-toyama.ac.jp

Advances in experimental medicine and biology 2012

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The inner blood-retinal barrier (inner BRB) is created by complex tight junctions of retinal capillary endothelial cells. Although this barrier prevents the free diffusion of substances between the circulating blood and the neural retina, the inner BRB efficiently supplies nutrients to the retina and removes endobiotics and xenobiotics from the retina to maintain a constant milieu in the neural retina. We review herein the molecular structure and transport mechanism at the inner BRB.

Citation

Ken-ichi Hosoya, Masanori Tachikawa. The inner blood-retinal barrier: molecular structure and transport biology. Advances in experimental medicine and biology. 2012;763:85-104