Yuwen Zeng, Laijun Zhang, Yanchuan Zhao, Chuanfa Ni, Jingwei Zhao, Jinbo Hu
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
Journal of the American Chemical Society 2013 Feb 27An unprecedented silver-mediated vicinal trifluoromethylation-iodination of arynes that quickly introduces CF(3) and I groups onto aromatic rings in a single step to give o-trifluoromethyl iodoarenes has been developed. A new reactivity of AgCF(3) has been revealed, and 2,2,6,6-tetramethylpiperidine plays an important role in this difunctionalization reaction.
Yuwen Zeng, Laijun Zhang, Yanchuan Zhao, Chuanfa Ni, Jingwei Zhao, Jinbo Hu. Silver-mediated trifluoromethylation-iodination of arynes. Journal of the American Chemical Society. 2013 Feb 27;135(8):2955-8
PMID: 23398454
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