Cancer stem cells are self-renewing, tumorigenic cells at the apex of tumor hierarchies, and postulated to be quiescent in many tumor types. This issue of Cancer Discovery highlights a study that links the presentation of kinetochores within mitosis to an essential requirement for BUB1B/BubR1, broadening our understanding of the cell-cycle machinery in cancer stem cells.
Monica Venere, Tyler E Miller, Jeremy N Rich. Mitotic control of cancer stem cells. Cancer discovery. 2013 Feb;3(2):141-4
PMID: 23400473
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