Acid-catalyzed hydration of alkynes in aqueous microemulsions.

Zackaria Nairoukh, David Avnir, Jochanan Blum

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

ChemSusChem 2013 Mar

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Terminal aromatic alkynes are converted rapidly into ketones in a regioselective manner by treatment of their microemulsions with 0.33 M mineral acid between 80 and 140 °C. Internal and aliphatic acetylenes are likewise hydrated, but require longer reaction periods. The products are easily isolated from the reaction mixtures by phase separation. Replacement of H2 O by D2 O leads to the formation of trideuteriomethyl ketones. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.