Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection.

Glen C Ulett, Makrina Totsika, Kolja Schaale, Alison J Carey, Matthew J Sweet, Mark A Schembri

School of Medical Sciences, Centre for Medicine and Oral Health, Griffith University, Southport, Australia.

Current opinion in microbiology 2013 Feb

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Urinary tract infections (UTI) are among the most common infectious diseases of humans and are the most common nosocomial infections in the developed world. It is estimated that 40-50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic Escherichia coli (UPEC) is the primary cause of UTI. This review presents an overview of recent discoveries related to the primary virulence factors of UPEC and major innate immune responses to infection of the lower urinary tract. New and emerging themes in UPEC research are discussed in the context of the interface between host and pathogen. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Glen C Ulett, Makrina Totsika, Kolja Schaale, Alison J Carey, Matthew J Sweet, Mark A Schembri. Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Current opinion in microbiology. 2013 Feb;16(1):100-7