Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line.

De Chang, Huiwen Xu, Yinghua Guo, Xuege Jiang, Yan Liu, Kailong Li, Chunxiao Pan, Ming Yuan, Junfeng Wang, Tianzhi Li, Changting Liu

In vitro cellular & developmental biology. Animal 2013 Mar

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Simulated microgravity (SM) has been implicated in affecting diverse cellular pathways. Although there is emerging evidence that SM can alter cellular functions, its effect in cancer metastasis has not been addressed. Here, we demonstrate that SM inhibits migration, gelatinolytic activity, and cell proliferation of an A549 human lung adenocarcinoma cell line in vitro. Expression of antigen MKI67 and matrix metalloproteinase-2 (MMP2) was reduced in A549 cells stimulated by clinorotation when compared with the 1×g control condition, while overexpression of each gene improves ability of proliferation and migration, respectively, under SM conditions. These findings suggest that SM reduced the metastatic potential of human lung adenocarcinoma cells by altering the expression of MKI67 and MMP2, thereby inhibiting cell proliferation, migration, and invasion, which may provide some clues to study cancer metastasis in the future.

Citation

De Chang, Huiwen Xu, Yinghua Guo, Xuege Jiang, Yan Liu, Kailong Li, Chunxiao Pan, Ming Yuan, Junfeng Wang, Tianzhi Li, Changting Liu. Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line. In vitro cellular & developmental biology. Animal. 2013 Mar;49(3):170-7